Vulvovaginal candidiasis in women of reproductive age: immunological aspects of modern algorithms for examination and treatment

immunological defense complex is involved: the role of complement, T-lymphocytes, NK-cells noted. Of particular importance among immune factors interferon-γ, which able to limit reproduction Candida fungi in early stages infection by stimulating response. This due fact that interferon-γ strongest stimulator effector functions macrophages (microbicidal activity, cytokine production), increases expression histocompatibility molecules MHCI and MHCII, as well adhesion on endothelial cells, increasing permeability. Thus, rate development severity pathological process depend state body’s defenses. The use antibiotics, glucocorticoids cytostatics, radiation therapy can enhance adhesive properties yeast fungi. choice treatment for VVC should be based results a comprehensive diagnosis, taking into account form risk disease. Local immunity impairment innate quality vaginal epitheliocytes currently one most significant VVC. also explains availability sufficient drugs etiotropic therapy, does not affect its recurrence rate. topical immunomodulators very promising method overcoming therapeutic failures genital candidiasis.